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| Q. | What is Flavay®? | ||||||||
| A. | Flavay® is the original, highly specialized, nutritional
complex of pairs and triples of a specific molecule called "flavan-3-ol,"
isolated from natural extracts, and that has been extensively tested and
examined clinically for biological antioxidant protection, collagen strengthening,
tissue rebuilding and other health producing outcomes. |
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| Q. | How safe is Flavay®? | ||||||||
| A. | After more than 60 years of human use, no adverse effects
have been observed. Furthermore, intensive biological, toxicological, pharmacological
and analytical research was conducted for the purpose of registering it
as a medicine in France and other countries in Europe. In one study, daily
doses of up to 35,000 mg for six months were determined to cause no adverse
effects. |
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| Q. | How does Flavay® affect the liver? | ||||||||
| A. | Flavay® helps protect hepatic capillaries (the smallest blood vessels in the liver) from free radical damage and activates liver antioxidant enzyme systems. A study of twenty patients with cirrhosis of the liver showed that a daily intake of 300 mg of Flavay® can help to decrease capillary fragility of the liver. |
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| Q. | Does Flavay® have any contraindications? | ||||||||
| A. | No, Flavay® has no known contraindications (conditions
under which it should not be used). Flavay® is completely safe and
nontoxic. In fact, clinical trials have been conducted in which pregnant
women (troubled by varicose veins and other circulatory problems in the
legs) safely used Flavay®. If you are taking anticoagulant medication, you should ask your doctor
whether you may also use Flavay® as it will also decrease the reactivity
("stickiness") of blood platelets. |
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| Q. | Should I consult with my doctor before taking Flavay®? | ||||||||
| A. | Yes, please consult your doctor before starting any course of supplementation or diet change, particularly if you are currently under medical care. If you have or suspect you may have a health problem, you should consult your doctor. If you are taking anticoagulant medication, you should ask your doctor
whether you may also use Flavay® as it will also decrease the reactivity
("stickiness") of blood platelets. |
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| Q. | Can the active ingredients in Flavay® be obtained in food? | ||||||||
| A. | Yes and No. The active flavan-3-ol molecules in Flavay® can be found especially in the fibrous and woody parts of naturally-ripened, raw fruits and vegetables, and in the skins of seeds, nuts and fruits. Unfortunately, our fruits and vegetables are typically deficient of these active polyphenol molecules due to our modern methods of distributing food—which result in fruits and vegetables that have been harvested while unripe. Another cause for deficiency is cooking, which destroys the active polyphenols. What's more, the skins of seeds, nuts and fruits are the parts of our food that we generally discard or spit out. Actually, the best "food" source is red wine. The active principles in Flavay® are at the center of the curious phenomenon known as the "French Paradox." Red wine is a carrier of these healthy polyphenols. So, why not just drink red wine to get your daily dose of flavan-3-ol? Alcoholic beverages are not ideal as dietary supplements due to potential abuse, dependency and toxicity as a result of over consumption. And, while alcohol can compromise liver function, Flavay® actually helps protect hepatic capillaries (the smallest blood vessels in the liver) from free radical damage and activates liver antioxidant enzyme systems. The point is that Flavay® provides specific protection to the liver, and red wine does not. So, while drinking some red wine is a reasonably healthy for most adults, the best way to guarantee a consistent daily intake of flavan-3-ol polyphenols is in its pure, concentrated form—Flavay®. |
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| Q. | Is Flavay® Patented? | ||||||||
| A. | Yes, there are many patents. In 1948 Dr. Jack Masquelier
received a French Patent which described a method to extract the active
principles in Flavay® from the bark of the pinus Maritima.
In 1970 Dr. Masquelier received another French Patent which described
an even more efficient extraction method of the active principles from
the seeds of the vitis vinifera grapes. On October 6, 1987 Dr.
Masquelier was awarded U.S. Patent No. 4,698,360 to describe the proanthocyanidins
in Flavay® for use as a powerful antioxidant, "which has a
radical scavenger effect."
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| Q. | Have proper research studies proven Flavay's™ effectiveness? | ||||||||
| A. | Yes, Flavay® is backed by more than 60 years of research
and human use, patents for therapeutic uses and extensive testing for safety.
The original French and European brands were registered in France as over-the-counter
medications and it has therefore been consumed in Europe under medical supervision
for decades with no reports of adverse side effects. |
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| Q: | "What is the difference between the terms, OPC and polyphenol? In some cases it appears synonymous and in others there appears to be a distinction. On some labels it will say OPC, but in the supplement facts, it says grape seed extract (vitis vinifera) 95% polyphenols. I am confused." | ||||||||
| A: | It's confusing because these terms are used inaccurately in the marketplace. "95% polyphenols" is a meaningless expression in a scientific context. However, it does illustrate a problem: In most cases, the following terms are used interchangeably for commercial interests—or by mistake—and their differences have truly lost all scientific meaning in the marketplace:
Therefore, when reading product labels, magazine articles and many popular books, these scientific terms should be considered as generic words and not scientific whatsoever. |
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| Q. | Are OPCs (or, proanthocyanidins) the same as "grape seed extract" or "pine bark extract" products? | ||||||||
| A. | Yes (in the marketplace) and No (in the scientific context). Because of commercial interests—or by mistake— the terms, OPCs and proanthocyanidins, have truly lost all of their scientific meaning in the marketplace. In most cases, suppliers and retailers confuse grape seed extracts as being synonymous with opcs or proanthocyanidins. However, the terms are not the same in the scientific context. "Grape seed extract" is a nonscientific term that has no specific meaning—other than crushed seeds which can be toxic and oxidizing if not properly manufactured. However, OPCs (short for oligomeric proanthocyanidins) is the active ingredient that was discovered by Dr. Masquelier and proven to have powerful antioxidant properties and other health producing benefits. It's important to note that independent testing found no
active OPCs in a leading American brand of grape seed extract—even
though it's aggressively marketed as a branded OPC product. |
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| Q. | Is Flavay® the same as "grape seed extract" or "pine bark extract"? | ||||||||
| A. | No. "Grape seed extract" is a vague, nonspecific term that really has no scientific value. In fact, crude "grape seed extract" (and "pine bark extract") imitations are virtually worthless to the consumer without active and naturally-derived oligomeric proanthocyanidins with antioxidant capacity. Consumers should be aware that untested and crude "grape seed extracts," "pine bark extracts" and other offshoot imitations are manufactured from a wide variety of methods, using various solvents and passed off with the scientific research conducted on Flavay® (see Resivit™ and Flavan™ below).
However, Flavay® is a very specific molecular complex that is scientifically defined and manufactured according to the original process developed and patented by Dr. Jack Masquelier in France, which captures the naturally-derived oligomeric proanthocyanidins from their plant sources. Independent laboratory testing demonstrates that Flavay® scores
the highest as an antioxidant and as a free radical scavenger, which is
precisely the free radical scavenging effect that Dr. Masquelier
invented and claimed in U.S. Patent 4,698,360. |
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| Q. | What are Resivit™ and Flavan™? | ||||||||
| A. | The early French brand names.
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| Q. | Is Flavay® the same as OPCs (or proanthocyanidins) in the marketplace? | ||||||||
| A. | No. OPCs (short for oligomeric proanthocyanidins) is a term that covers many different and complex molecules. However, due to commercial interests—or by mistake—the terms "OPCs" and "proanthocyanidins" are often abused and misunderstood and have therefore lost all of their scientific meaning in the marketplace.
It's true that "OPCs" is the group of active principles that
is responsible for bringing the "grape seed extract" category
of products to fame. However, independent testing found no
active OPCs in a leading American brand of grape seed extract,
even though it's labeled and aggressively marketed as a branded OPC product.
Consumers should also be aware that some manufacturers of grape seed and pine bark extracts have devised ways to artificially boost the proanthocyanidin numbers for their extracts in a test tube (in vitro, which is outside the living body and in an artificial environment ). However, there is no scientific research to show whether the human body benefits from this artificial boost. Flavay® is unique. Flavay® is derived from the original manufacturing process developed and patented by Dr. Jack Masquelier in France, which captures the naturally-derived oligomeric proanthocyanidins from their plant sources. For well over 60 years, each batch has been routinely and extensively tested and analyzed to guarantee consistency, potency and purity. Independent laboratory testing demonstrated that Flavay® scores
the highest as an antioxidant and as a free radical scavenger, which is
precisely the free radical scavenging effect that Dr. Masquelier
invented and claimed in U.S. Patent 4,698,360. |
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| Q. | Do you have additional questions about Flavay®? | ||||||||
| A. | Click here to submit a question or call 1-800-200-1203. |
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| REFERENCES: | Top |
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| Masquelier, J. Plant extract with
a proanthocyanidins content as a therapeutic agent having radical scavenging
effect and use thereof. U.S. Patent No. 4,698,360, 1987. Masquelier, J. A lifetime devoted to OPC and Pycnogenols. Alfa Omega Editrice, Pub., 1996. Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice, Publishers, 1995. Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats Publishing, Inc., 1997. The International Nutrition Company Special Report, "Pine vs. Pine Comparative Analysis between Masquelier's Original Pine Bark OPCs and another leading brand pine bark extract," Oc. 1998. PhytoChem Technologies, Inc., Chelmsford, Massachusetts, Ju. 1998. The International Nutrition Company Special Report,"Masquelier's Original OPCs and ten grape seed extracts; an independent, reproducible state-of-the-art comparative analysis," No. 1997. Facino RM, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung, 44: 592-601, 1994. Havsteen, B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol, 32:1141-48, 1983. Masquelier, J., et al. Flavonoids et Pycnogenols Int J Vit Nut Res, (49)3:307-311, 1979. Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol. 25(2):135-9, 1987. Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica Report, 1971. Laparra, J., et al., Acta Therapeutica, 4:233, 1978. Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects 143010 & 143021; Feb. 1989. Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover, Germany, 1967-1971. Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990. |
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