Flavay® helps to normalize the immune system at the cellular level...

A strong immune system is the cornerstone of good health as it protects your body against disease. There are several important ways that Flavay® can nourish and invigorate your immune system. First, Flavay® helps to normalize immune functions at the cellular level. Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses and parasites. However, if nitric oxide is overproduced it turns on its host and damages the macrophages—thereby impairing immune function. Thus, phrases such as "double-edged sword" are frequently applied to nitric oxide in health and disease. This emphasizes the importance of another way that Flavay® benefits the immune system: regulating nitric oxide in the body. Research shows that Flavay® can help to maintain the optimal level of this free radical by helping the body to produce adequate levels—and to neutralize nitric oxide where it does harm.

Finally, by increasing the activity of vitamins C and E in the body, Flavay® helps the body maintain its antioxidant defenses, giving the immune system more ammunition to fight infection.

How Your Immune System Works

Although it's called a "system," the immune system is not associated with one particular organ but it's a collection of cells that "speak" to one another—and with the rest of the body— through chemical messengers (the immunotransmitters) and thereby work in close harmony to protect the body from the harmful effects of bacteria, viruses, parasites and environmental toxins.

The most important components of the immune cells are the white blood cells (lymphocytes), which include T-cells, B-cells and macrophages. Macrophages are the immune system's foot soldiers, capable of engaging in hand-to-hand combat as they literally gobble up invaders to destroy them.

The white blood cells depend upon immunotransmitters called "cytokines" to communicate with one another and to coordinate their ferocious activity. Cytokines are to the immune system what neurotransmitters are to the brain. Just as the brain relies upon neurotransmitters to exchange information among its neurons and with the rest of the body, so your immune system depends upon cytokines.

When your body is threatened by an invasion, cytokines signal your immune system to mobilize reserve troops of white blood cells. When the invasion is over, your cytokines are responsible for sending the signals to stop mobilizing the troops. In other words, these immunotransmitters coordinate your white blood cells, boosting their activity at times of infection, injury, or other demands and reining them back in after battle.

Flavay® Normalizes Immune Cell Functions and
Actually Boosts Immune Function

When the body fights off an infection, the cytokines go to work, sending messages to the brain that cause more white blood cells to mobilize. The more white blood cells your body activates, the more free radicals they produce. These free radicals are among your immune system's most powerful weapons, as a response to injury and during times of disease, emotional stress and aging. Research demonstrates that Flavay® has the power to restore cytokine imbalances and can normalize white blood cell activity, thereby normalizing immune function.

Flavay® Scavenges the Body's Terrorists:
Rampaging Free Radicals

Free radicals are like pellets of poison that destroy invaders by interfering with their cellular machinery, literally dissolving or breaking down the genetic material of bacteria, toxins and viruses.

When all is going well, the immune system is capable of identifying foreign invaders such as viruses and bacteria by accurately "reading" molecular codes found on cell surfaces. These molecular codes are like flags of different armies, and the immune system will not attack a cells if it "reads" a flag belonging to the body's own host army. Unfortunately, however, free radicals can interfere with the biological components of our healthy cells, just as they destroy invaders. This leads to many diseases.

Nitric Oxide Toxicity and Abnormal Immune Responses

Contemporary research shows that elevated levels of nitric oxide (sometimes referred to as "NO") appear to contribute to a number of seemingly different disorders that all have a common element of abnormal immune or inflammatory responses.

Studies of arthritis, colitis, and other inflammatory disorders have all demonstrated elevated levels of nitric oxide synthesis. In the case of arthritis, nitric oxide has been implicated in the destruction of the pericellular and extracellular matrix of cartilage in arthritis.

Arthritis is an umbrella term for more than 100 different conditions that produce either inflammation of connective tissue (joints and tendons) or degeneration of the articular cartilage, a wearing down of the protective covering that cushions the ends of bones, allowing bones to rub together without causing damage to the joints.

When joints become arthritic, they become inflamed and enlarged, interfering with the normal flow of blood. For example, when you bend an arthritic knee, you cut off blood flow to the area which sets into motion of a chain of events that will lead to a burst of free radicals when the blood flow returns (known as "reperfusion injury"). When you release the knee, a proliferation of free radicals causes the area to become even more inflamed, contributing to the degeneration of the joint, which becomes more swollen and worn down.

High levels of nitric oxide have also been implicated in the inflammation that is associated with asthma. Asthmatics exhale significantly higher levels of nitric oxide and type II nitric oxide synthase (also known as "NOS") expression is increased in biopsy specimens from asthmatics.

It's long been recognized that nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, excessive amounts of nitric oxide can be deadly to the cardiovascular system and actually contribute to disease and inflammation. High levels of nitric oxide can restrict blood flow and promote production of more free radicals, including the dangerous peroxynitrate.

Flavay® can significantly scavenge nitric oxide radicals. However, as we'll discuss next, your body needs a certain amount of nitric oxide in order to maintain good health. Nitric oxide is paradoxical. It can both mediate normal physiological functions and it can be highly toxic. Nitric oxide can act as an anti-inflammatory under normal health conditions, but it can have the opposite effect and cause more inflammation to an already inflamed area when overproduced. The key, therefore, is to maintain the optimum balance of this double-edged sword, nitric oxide.

When the immune system's cytokines activate macrophages (the white blood cells capable of gobbling up invading viruses and bacteria), the macrophages produce large amounts of nitric oxide in the course of battle. Nitric oxide is a colorless gas produced by many different cells in the body that, depending on the situation, can be very good or very bad. Nitric oxide plays several important roles in the body:

• Nitric oxide is an important signaling molecule that turns genes on and off.
  
• By controlling the muscular tone of blood vessels, nitric oxide regulates the circulation and normalizes blood flow.
  
• Nitric oxide modulates communication between brain cells and is instrumental in helping us concentrate and learn new information, and also in maintaining memory.
  
• When produced by immune cells, nitric oxide fights infection, kills tumor cells and promotes wound healing.
  
• Nitric oxide is essential for perceiving pleasure and pain, and it helps translate sexual excitement into penile erections.
  
• Nitric oxide aids in digestion of food by helping to control gastric movements.

But nitric oxide can be very destructive under other circumstances:

• Nitric oxide restricts blood flow.
  
• When produced in excess by immune cells, nitric oxide can trigger chronic inflammation, which can cause arthritis, colitis, inflammatory bowel disease and possibly cancer.
  
• Nitric oxide promotes production of more free radicals.
  
• In the brain, nitric oxide can hamper mental function and cause memory loss and brain aging.

The real trouble starts when nitric oxide encounters the superoxide free radical and becomes peroxynitrate, which destroys antioxidants like glutathione, vitamin E and common flavonoids, and damages proteins in the body. The good news is that Flavay® scavenges peroxynitrate and has a remarkable modulatory effect on nitric oxide—helping to maintain optimal levels in the body and neutralizing this free radical where it does harm.

"Radical Scavenger Effect" of Flavay®
Protected by U.S. Patent No. 4,698,360

Flavay® is the actual product—used in the experiments—by which Dr. Jack Masquelier established and patented the "radical scavenger effect."

Flavay's™ strong antioxidant power is patented—as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation. That means that your immune system works better, your joints hurt less, and your blood flows better, all because of Flavay®.

Flavay Increases the Activity of Vitamins C and E

Flavay® recycles and significantly extends the lifetime of vitamin C and potentiates vitamin E, and thereby creates a more powerful, synergistic antioxidant defense in the body. This is important because vitamins C and E are key players in the body's protective antioxidant army.

Antioxidants fight corrosive and destructive forces that constantly work to break down our bodies. Overwhelming scientific evidence demonstrates that those of us who eat a diet rich in antioxidants and take antioxidant supplements will live longer and healthier lives. Working as a defensive army, antioxidants work together in the body to maintain our health and vigor by protecting us from damage caused by rampaging free radicals which, like terrorists, injure healthy cells and tissues.

Don't underestimate the threat that free radicals pose to our health. Contemporary scientists now believe that free radicals are causal factors in nearly every known disease, from heart disease to arthritis to Parkinson's to Alzheimer's to ALS to multiple sclerosis to cataracts to the aging process itself.

As a free radical fighter, Flavay® comes to the aid of the body more quickly than other antioxidants, reducing the potential for free radical damage and the ravages of aging. Flavay® also possesses more reactive sites for neutralizing free radicals than other known antioxidants. Furthermore, Flavay® permits reactivity with both positively and negatively charged free radical species. What this means is that Flavay® can “quench” or “scavenge” (neutralize) a broad variety of free radicals. Highly reactive as an antioxidant in both lipid (fat) and aqueous (water) phases, Flavay® neutralizes oxygen free radicals and is a valuable protector of healthy cells in a variety of internal conditions. This is a unique property among antioxidants, as most work either in lipid or aqueous phases, but not both. As a free radical scavenger, Flavay® is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.

Flavay®: More Than 60 years of Protection

Now available in the United States, Flavay® is the actual polyphenol that has been licensed and sold in France since 1950. And, Flavay Plus® utilizes the dynamic interplay between Flavay® and the other antioxidant nutrients and their co-factors in order to provide you and your family with the best that nutritional science has to offer for immune protection—in a convenient, cost effective capsule.

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